Methods
A close reading of thirty years of Achilles transection work in rats, and of how much of it shares an institution, a surgical protocol, and a set of priors.
Jonah Adeyemi · Feb 18, 2026 · 7 min
Methods
Dextran sulphate sodium strips the mouse gut barrier on a schedule. That reproducibility is exactly why the model is useful, and exactly why it is not a disease.
Mara Ellison · Feb 4, 2026 · 9 min
Column
Eight animals per arm is the working default across this field. It can detect only large effects — and when it does detect one, it almost certainly exaggerates it.
Owen McAllister · Jan 27, 2026 · 6 min
Explainer
Cultured human dermal fibroblasts sit in whatever you add to the medium. Intact skin is an organ whose entire job is to prevent that, and the gap is rarely addressed.
Clara Vasquez · Dec 18, 2025 · 8 min
History
A small rodent study, a review that cited it, a second review that cited the first, and twenty years later a claim that everybody knows and nobody has retested.
Rina Iyer · Jan 14, 2026 · 10 min
Evidence Review
Cathelicidins kill bacteria efficiently in low-salt buffer. Adding physiological salt and serum to the assay removes most of the headline, and most of the press releases.
Clara Vasquez · Nov 26, 2025 · 11 min
Evidence Review
Roughly a decade of mouse metabolic work from a handful of laboratories. The findings are interesting; the correcting literature simply has not been written yet.
Owen McAllister · Nov 5, 2025 · 9 min
Explainer
The question we get most often is the one we will not answer. Here is the reasoning, stated once, so we can point at it rather than re-argue it every month.
The Null Result editorial desk · Oct 15, 2025 · 5 min
